Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues

doi:10.5306/wjco.122832

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Sep 24, 2026; 17(9): 122832
Published online Sep 24, 2026. doi: 10.5306/wjco.122832

Table 1 Expression of proteins in lung cancer tissues (n = 40), n (%)

Protein	Positive case	Negative case
AKAP95	40 (100)	0 (0)
Cx43	39 (97.5)	1 (2.5)
SCF^FBXL2	40 (100)	0 (0)
SCF^FBXO31	29 (72.5)	11 (27.5)
CPSF5	40 (100)	0 (0)
CPSF6	40 (100)	0 (0)

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Table 2 Correlation analysis between tissue phenotype, differentiation, lymph node metastasis and protein expressions

Positive expression (n)	Phenotype (squamous cell carcinoma/adenocarcinoma/bronchioloalveolar carcinoma/small cell carcinoma)		Differentiation (low/medium/high)		Lymph node metastasis (yes/no)
Positive expression (n)	Cases	P value	Cases	P value	Cases	P value
AKAP95 (40)	17/12/4/7	NA	8/21/11	NA	21/19	NA
Cx43 (39)	16/12/4/7	0.361	8/20/11	0.915	20/19	0.348
SCF^FBXL2 (40)	17/12/4/7	NA	8/21/11	NA	21/19	NA
SCF^FBXO31 (29)	12/9/3/5	0.932	5/16/8	0.679	15/14	0.877
CPSF5 (40)	17/12/4/7	NA	8/21/11	NA	21/19	NA
CPSF6 (40)	17/12/4/7	NA	8/21/11	NA	21/19	NA

NA: Not available.

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Table 3 Correlation analysis between AKAP95, Cx43, SCF^FBXL2 and SCF^FBXO31

Correlated protein	Cases of expression level (n = 40)					Coefficients	P value
Correlated protein	-	±	+	++	+++	Coefficients	P value
AKAP95-SCF
AKAP95	0	5	14	19	2	/	/
SCF^FBXL2	0	3	14	17	6	-0.040	0.806
SCF^FBXO31	11	21	8	0	0	-0.346	0.029
Cx43-SCF
Cx43	1	5	16	16	2	/	/
SCF^FBXL2	0	3	14	17	6	-0.047	0.773
SCF^FBXO31	11	21	8	0	0	0.334	0.035

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Table 4 Correlation analysis between AKAP95, Cx43, CPSF5, and CPSF6

Correlated protein	Cases of expression level (n = 40)					Coefficients	P value
Correlated protein	-	±	+	++	+++	Coefficients	P value
AKAP95-CPSF
AKAP95	0	5	14	19	2	/	/
CPSF5	0	2	8	26	4	0.340	0.032
CPSF6	0	0	7	22	11	0.057	0.726
Cx43-CPSF
Cx43	1	5	16	16	2	/	/
CPSF5	0	2	8	26	4	0.113	0.487
CPSF6	0	0	7	22	11	0.114	0.485

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Citation: Deng ZF, Zhao L, Yuan Y, Li LK, Ge MY, Dou LD, Zhang JW, Wang D, Guo DB, An R, Zhang YX, Song B. Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues. World J Clin Oncol 2026; 17(9): 122832
URL: https://www.wjgnet.com/2218-4333/full/v17/i9/122832.htm
DOI: https://dx.doi.org/10.5306/wjco.122832

Deng ZF, Zhao L, Yuan Y, Li LK, Ge MY, Dou LD, Zhang JW, Wang D, Guo DB, An R, Zhang YX, Song B. Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues. World J Clin Oncol 2026; 17(9): 122832 [DOI: 10.5306/wjco.122832]

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