Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Oncol. Sep 24, 2026; 17(9): 122832
Published online Sep 24, 2026. doi: 10.5306/wjco.122832
Published online Sep 24, 2026. doi: 10.5306/wjco.122832
Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues
Zi-Feng Deng, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China
Zi-Feng Deng, Lei Zhao, Liang-Ding Dou, Jin-Wen Zhang, Dai Wang, Dong-Bei Guo, Ran An, Yong-Xing Zhang, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian Province, China
Lei Zhao, Ye Yuan, Li-Kun Li, Mu-Ya Ge, Bo Song, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, Nanjing 230032, Jiangsu Province, China
Co-first authors: Zi-Feng Deng and Lei Zhao.
Author contributions: Song B designed the research study; Deng ZF and Zhao L performed the research; Dou LD, Zhang JW and Yuan Y analyzed the data; Li LK and Ge MY contributed of pathological tissues; Wang D, Guo DB, An R and Zhang YX gave administrative support; Song B and Zhao L reviewed the manuscript; all authors have read and approved the final manuscript. Deng ZF and Zhao L jointly performed the research; Deng ZF wrote the manuscript, while Zhao L reviewed the manuscript; made equal contributions to the project; following a comprehensive deliberation involving all co-first authors, it has been mutually agreed that Deng ZF and Zhao L be designated as co-first authors.
AI contribution statement: We use GPT-5.6 Sol to polish the language of a small portion of the manuscripts. At the same time, we also entrust it to MedSci to ensure the language meets the standards. No AI tools were used to generate research data, analyze data, or draw conclusions. The author bears full responsibility for this.
Supported by National Natural Science Foundation of China, No. 82272349.
Institutional review board statement: This study was initially approved in 2007 and all participants were informed consent to collect tumor tissue and participate in subsequent studies between 2007-2009 by Shengjing Hospital of China Medical University. Due to multiple uses of the same batch of samples, Ethics Committee of Xiamen University School of Public Health re- examined and approved the study (No. SPHIRB-202001). We declare that our study adhered to the Declaration of Helsinki and we respect dignity, privacy, and rights of all participants.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: All original slices are kept by our laboratory. Please contact z63y94x@xmu.edu.cn for relevant data.
Corresponding author: Bo Song, PhD, Chief Physician, Professor, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, No. 1 Changfu Road, Nanjing 230032, Jiangsu Province, China. 23822520@qq.com
Received: May 6, 2026
Revised: August 5, 2026
Accepted: September 15, 2026
Published online: September 24, 2026
Processing time: 146 Days and 17.3 Hours
Revised: August 5, 2026
Accepted: September 15, 2026
Published online: September 24, 2026
Processing time: 146 Days and 17.3 Hours
Core Tip
Core Tip: This study links mechanistic findings to clinical evidence in lung cancer. Immunohistochemical analysis of 40 tumor specimens showed that AKAP95 was negatively correlated with the SCFFBXO31, whereas Cx43 was positively co