Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. May 24, 2025; 16(5): 105322
Published online May 24, 2025. doi: 10.5306/wjco.v16.i5.105322
Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1
Xiu Zhou, Lin-Qing Wang, Shuai Song, Mei Xu, Chang-Ping Li
Xiu Zhou, Lin-Qing Wang, Shuai Song, Mei Xu, Chang-Ping Li, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Co-first authors: Xiu Zhou and Lin-Qing Wang.
Author contributions: Zhou X and Wang LQ contributed equally as co-first authors; Zhou X designed the experimental plan, conducted relevant experiments, and wrote the original article; Wang LQ conducted relevant experiments, collected data and performed statistical analysis of data; Song S acquired materials, assisted in conducting experiments, and supplemented the article; Xu M assisted in completing experiments; Li CP supervised experiments and methods, and edited the article. All authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Clinical Trial Ethics Committee of Affiliated Hospital of the Southwest Medical University (Approval No.KY2025054).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Ping Li, MD, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. 506854209@qq.com
Received: January 18, 2025
Revised: March 4, 2025
Accepted: March 26, 2025
Published online: May 24, 2025
Processing time: 122 Days and 12.5 Hours
Core Tip

Core Tip: The main reason for gastric cancer (GC) is Helicobacter pylori (H. pylori). The annual global burden of GC continues to increase. Our study investigated the influence of deleted in malignant brain tumors 1 induced by H. pylori on the proliferation and metastasis of GC. Using human GC cells, we concluded that H. pylori promote GC cell proliferation, metastasis, and invasion through down-regulation of deleted in malignant brain tumors 1 and facilitates GC development through cell function experiments and gene expression experiments.