Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2021; 12(4): 272-281
Published online Apr 24, 2021. doi: 10.5306/wjco.v12.i4.272
Lenvatinib-induced multiorgan adverse events in Hurthle cell thyroid cancer: A case report
Muhammad Imran Butt, Abdulmohsen Mohammed Khalid Bakhsh, Quaid Johar Nadri
Muhammad Imran Butt, Abdulmohsen Mohammed Khalid Bakhsh, Quaid Johar Nadri, Department of Medicine, King Faisal Specialist Hospital, Research Centre, Al Faisal University, Riyadh 12713, Saudi Arabia
Author contributions: Butt MI is the primary endocrinology physician involved in the care of the patient, and he reviewed the literature and drafted the manuscript; Bakhsh MK is the endocrinology fellow who took informed written consent from the patient and collated and prepared the laboratory data for the manuscript; Nadri QJ offered nephrology consultation and care for the management of renal adverse events; all authors reviewed and approved the final version of the manuscript.
Informed consent statement: The patient provided a written informed consent. We conducted the study in accordance with the guidelines outlined in the declaration of Helsinki. This study was approved by the Institutional Ethics Committee of King Faisal Specialist Hospital and Research Centre (approval No. RAC 2200330).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad Imran Butt, FRCP, MD, MRCP, Doctor, Department of Medicine, King Faisal Specialist Hospital, Research Centre, Al Faisal University, Zahrawi St, Al Maather, Al Maazer, Riyadh 12713, Saudi Arabia. mimran74@hotmail.com
Received: December 22, 2020
Peer-review started: December 22, 2020
First decision: January 11, 2021
Revised: January 30, 2021
Accepted: March 7, 2021
Article in press: March 7, 2021
Published online: April 24, 2021
Core Tip

Core Tip: The present case study provides a unique learning and case management experience. Our patient had widespread metastasis from a histopathologically low-risk thyroid cancer coupled with two decades of survival despite noniodine-avid metastasis, treatment of renal metastasis with tyrosine kinase inhibitors, and the development of multisystem adverse events, including rare nephrotic syndrome.