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World J Clin Oncol. Nov 24, 2021; 12(11): 1000-1008
Published online Nov 24, 2021. doi: 10.5306/wjco.v12.i11.1000
Consensus molecular subtypes of colorectal cancer in clinical practice: A translational approach
Guillermo Valenzuela, Joaquín Canepa, Carolina Simonetti, Loreto Solo de Zaldívar, Katherine Marcelain, Jaime González-Montero
Guillermo Valenzuela, Joaquín Canepa, Carolina Simonetti, Loreto Solo de Zaldívar, Katherine Marcelain, Jaime González-Montero, Basic and Clinical Oncology Department, University of Chile, Santiago 8380453, Chile
Author contributions: Valenzuela G wrote this manuscript, created figures and tables; Canepa J, Solo de Zaldívar L, Simonetti C, Marcelain K, and González-Montero J collected data and references and critically revised the manuscript; all authors approved the final version of the manuscript for publication.
Supported by Agencia Nacional de Investigación y Desarrollo de Chile, Fondo Nacional de Investigación y Desarrollo en Salud, FONIS, No. SA20I0059.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jaime González-Montero, MD, PhD, Assistant Professor, Doctor, Basic and Clinical Oncology Department, University of Chile, Independencia 1027, Casilla 70058, Santiago 8380453, Chile. jagonzalez@ug.uchile.cl
Received: June 24, 2021
Peer-review started: June 24, 2021
First decision: August 8, 2021
Revised: August 11, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 24, 2021
Core Tip

Core Tip: Colorectal cancer has a variable response to different treatments that could be explained by genetic and molecular heterogeneity in the neoplasm. Recently, a novel classification according to consensus molecular subtype has been proposed to explain this neoplasm heterogeneity. From a clinical oncology perspective, this classification opens opportunities to resolve some current clinical questions in the treatment of colorectal cancer.