Zhou SQ, Luo LX. TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells. World J Clin Oncol 2024; 15(2): 175-177 [PMID: 38455138 DOI: 10.5306/wjco.v15.i2.175]
Corresponding Author of This Article
Lian-Xiang Luo, PhD, Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 East Wenming Road, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn
Research Domain of This Article
Cell Biology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Feb 24, 2024; 15(2): 175-177 Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.175
TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells
Shu-Qing Zhou, Lian-Xiang Luo
Shu-Qing Zhou, The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China
Lian-Xiang Luo, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
Author contributions: Luo LX conceived and designed the editorial; Zhou SQ wrote the editorial; Luo LX reviewed the paper and provided comments; All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Xiang Luo, PhD, Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 East Wenming Road, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn
Received: December 9, 2023 Peer-review started: December 9, 2023 First decision: December 18, 2023 Revised: December 27, 2023 Accepted: January 30, 2024 Article in press: January 30, 2024 Published online: February 24, 2024
Abstract
Zhuo et al looked into the part of transmembrane 9 superfamily member 1 (TM9SF1) in bladder cancer (BC), and evaluated if it can be used as a therapeutic target. They created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth, movement, invasion, and cell cycle advancement. Their results show that TM9SF1 can boost the growth, movement, and invasion of BC cells and their access into the G2/M stage of the cell cycle. This research gives a novel direction and concept for targeted therapy of BC.
Core Tip: The transmembrane 9 superfamily member (TM9SF) TM9SF family's biological function has not been investigated yet. However, some studies have suggested that its expression could be associated with the emergence and progression of tumors. This article used various experimental methods, such as CCK8, wound healing test, transwell test, and flow cytometry, to explore the effect of TM9SF1 on the biological behavior of bladder cancer (BC), in order to offer a novel approach for the treatment of BC.
