Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2022; 13(1): 62-70
Published online Jan 24, 2022. doi: 10.5306/wjco.v13.i1.62
Late recurrence of localized pure seminoma in prostate gland: A case report
Abinav Baweja, Nataliya Mar, Arash Rezazadeh Kalebasty
Abinav Baweja, Nataliya Mar, Arash Rezazadeh Kalebasty, Hematology/Oncology, UCI Medical Center, University of California, Orange, CA 92868, United States
Author contributions: All authors have made equal contributions, including literature search, article writing; all authors support for the publication of this manuscript.
Informed consent statement: Informed consent was obtained from the patient and documented for the purposes of the research.
Conflict-of-interest statement: There are no conflicts of interest to report from the authors of the manuscript.
CARE Checklist (2016) statement: All checklist items were completed to satisfy the requirements for publication.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arash Rezazadeh Kalebasty, MD, Doctor, Hematology/Oncology, UCI Medical Center, University of California, Irvine Chao Family Comprehensive Cancer Center 101 The City Dr S, Orange, CA 92868, United States. arez@uci.edu
Received: April 2, 2021
Peer-review started: April 2, 2021
First decision: August 18, 2021
Revised: September 22, 2021
Accepted: December 28, 2021
Article in press: December 28, 2021
Published online: January 24, 2022
Abstract
BACKGROUND

Late relapses of early-stage germ cell tumors are rare. Most patients (-85%) with stage I seminoma are cured by radical orchiectomy. The detection of late relapse is challenging given the relative rarity of this phenomenon, and the fact that patients who have completed surveillance are usually not undergoing regular oncologic workup nor imaging. While many treatment options do exist for a patient with late relapse of seminoma, surgery is typically the mainstay as these tumors are generally thought to be more chemo-resistant.

CASE SUMMARY

In this article, we describe the management of a patient with an early-stage pure seminoma who was subsequently identified to have a recurrence two decades later. We provide a review of the literature not only focused on clinical factors and biology, but also the management of late recurrences specifically in pure seminoma and in prostate gland.

CONCLUSION

There is a paucity of data and treatment recommendations for this clinical entity, and a multidisciplinary approach emphasizing subspecialty expert consultation and patient education is imperative.

Keywords: Late recurrence of pure seminoma, Pure seminoma, Seminoma, Primary prostatic seminoma, Germ cell tumor relapse, Treatment of relapsed seminoma, Biology of pure seminoma, Seminoma tumor markers, Case report

Core Tip: This case report describes of a patient with early-stage pure seminoma subsequently identified to have a recurrence within the prostate over two decades later. We provide a robust review of the literature focused on clinical factors, biology, and management of late recurrences specifically in pure seminoma and in prostate gland. There remains a lack of consensus data on treatment recommendations for this clinical disease. As such, a multidisciplinary approach emphasizing subspecialty expert consultation and patient education is imperative.