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Copyright ©2010 Baishideng Publishing Group Co.
World J Gastrointest Pharmacol Ther. Oct 6, 2010; 1(5): 107-111
Published online Oct 6, 2010. doi: 10.4292/wjgpt.v1.i5.107
Figure 1
Figure 1 Depending on the microenvironment, macrophages could follow different activation processes. Classical M1 activation is induced by bacterial products or pro-inflammatory cytokines as tumor necrosis factor α or IFNγ. Regulatory M2b activation is induced by glucocorticoids, prostaglandins or interleukin (IL)-10. Finally, reparative M2a activation depends mainly on IL-4 and IL-13. Since these phenotypes could be redirected, the modulation of macrophage phenotype could be a promising therapeutical approach for the treatment of the systemic effects of acute pancreatitis. TNFα: Tumor necrosis factor α.