Systematic Reviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. May 6, 2016; 7(2): 283-293
Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.283
Disaccharidase activity in children undergoing esophagogastroduodenoscopy: A systematic review
Taylor Daileda, Peter Baek, Morgan E Sutter, Kalpesh Thakkar
Taylor Daileda, Peter Baek, Morgan E Sutter, Kalpesh Thakkar, the SONIC Gut Research Group, Houston, TX 77479, United States
Author contributions: Daileda T, Sutter ME and Thakkar K contributed to the collection of data, study design, analysis of data, drafting the manuscript, and editing the manuscript; Baek P and contributed to the collection of data, study design, and editing the manuscript; Sutter ME contributed to the study design and editing the manuscript; all authors approved the final version of the manuscript.
Conflict-of-interest statement: No funding or conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Dryad repository, will provide a permanent, citable and open-access home for the dataset. All data for this systematic review was gathered from included studies.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kalpesh Thakkar, MD, the SONIC Gut Research Group, 1803 Cambria Lane, Sugar Land, Houston, TX 77479, United States. thakkarsmail@gmail.com
Telephone: +1-281-7255970 Fax: +1-281-7255971
Received: July 24, 2015
Peer-review started: July 27, 2015
First decision: August 25, 2015
Revised: January 15, 2016
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 6, 2016
Core Tip

Core tip: Intestinal disaccharide analysis of duodenal biopsy specimens are often obtained during esophagogastroduodenoscopy (EGD) in children. In our review examining 34753 disaccharide assays the overall proportion of lactase deficiency was 39.2%, sucrase deficiency was 9.0%, maltase deficiency was 12.6% and palatinase deficiency was 9.1% in children. The impact of EGD with disaccharide analysis on treatment plans, quality of life, improvement of gastrointestinal symptoms, and cost-effectiveness has not been well studied. There is also little published data on Hispanic children undergoing EGD with disaccharide analysis.