Published online Feb 15, 2015. doi: 10.4291/wjgp.v6.i1.13
Peer-review started: May 27, 2014
First decision: June 28, 2014
Revised: October 3, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 15, 2015
Core tip: Ulcerative colitis (UC) and Crohn’s disease are the major forms of inflammatory bowel diseases (IBD). Tests sometimes invasive are routine for the diagnosis and care of patients with IBD. The employment of non-invasive biomarkers is needed. We describe biomarkers assessed in UC, with special reference to acute-phase proteins and serologic markers and thereafter, we describe the new biological markers. The progress of molecular biology tools have revolutionised the field of the biomarker. The techniques available for biomarkers development are genomics and proteomics. Correlating serologic markers with genotypes and clinical phenotypes should enhance our understanding of pathophysiology of UC.