Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.450
Revised: July 2, 2014
Accepted: July 17, 2014
Published online: November 15, 2014
Core tip: The importance of biomarkers of Barrett’s esophagus is to provide identification of the disease, estimate the risk of malignant transformation, predict the response to therapy, and indicate the overall survival-prognosis for esophageal adenocarcinoma patients. Proposed predictive and prognostic markers do not allow stratification of gastroesophageal reflux disease patients for progression, outcome, and effectiveness of therapy in clinical practice. The aim of this short review is to discuss the current knowledge regarding proposed biomarkers to improve prognostic and predictive therapeutic approaches, with a focus on the pathophysiologic mechanisms.