Biomarkers of Barrett's esophagus

doi:10.4291/wjgp.v5.i4.450

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Nov 15, 2014 (publication date) through Apr 25, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 450-456
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.450

Biomarkers of Barrett's esophagus

Yasser Mahrous Fouad, Ibrahim Mostafa, Reem Yehia, Hisham El-Khayat

Yasser Mahrous Fouad, Reem Yehia, Gastroenterology and Hepatology Unit, Tropical Medicine Department, Minia University, Minia 11432, Egypt

Ibrahim Mostafa, Hisham El-Khayat, Gastroenterology and Hepatology Department, Theodore Research Institute, Cairo 11435, Egypt

Author contributions: All authors contributed to the manuscript; Fouad YM and Yehia R collected the data; Mostafa I and El-Khayat H revised the whole manuscript.

Correspondence to: Yasser Mahrous Fouad, MD, Professor of Gastroenterology and Hepatology Unit, Tropical Medicine Departement, Minia University, Main Road, Minia 11432, Egypt. yasserfouad10@yahoo.com

Telephone: +20-1-114721500 Fax: +20-1-114721500

Received: December 28, 2013
Revised: July 2, 2014
Accepted: July 17, 2014
Published online: November 15, 2014

Core Tip

Core tip: The importance of biomarkers of Barrett’s esophagus is to provide identification of the disease, estimate the risk of malignant transformation, predict the response to therapy, and indicate the overall survival-prognosis for esophageal adenocarcinoma patients. Proposed predictive and prognostic markers do not allow stratification of gastroesophageal reflux disease patients for progression, outcome, and effectiveness of therapy in clinical practice. The aim of this short review is to discuss the current knowledge regarding proposed biomarkers to improve prognostic and predictive therapeutic approaches, with a focus on the pathophysiologic mechanisms.