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World J Gastrointest Pathophysiol. Aug 15, 2014; 5(3): 373-379
Published online Aug 15, 2014. doi: 10.4291/wjgp.v5.i3.373
Published online Aug 15, 2014. doi: 10.4291/wjgp.v5.i3.373
Oxidative and nitrosative stress enzymes in relation to nitrotyrosine in Helicobacter pylori-infected humans
Anders Elfvin, Anders Edebo, Peter Hallersund, Anna Casselbrant, Lars Fändriks, Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, 416 85 Gothenburg, Sweden
Anders Elfvin, Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, 416 85 Gothenburg, Sweden
Author contributions: Elfvin A and Edebo A performed all the gastroscopies; Elfvin A, Hallersund P and Casselbrant A performed the laboratory work, and analysis; Elfvin A and Fändriks L designed the study; Fändriks L coordinated the study and provided financial support; Elfvin A and Hallersund P wrote the manuscript; all authors were involved in editing the manuscript.
Supported by The grants financially from the Swedish Medical Research Council and the Gothenburg Medical Society
Correspondence to: Dr. Anders Elfvin, MD, PhD, Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Diagnosroad 15, 416 85 Gothenburg, Sweden. anders.elfvin@vgregion.se
Telephone: +46-31-3438073 Fax: +46-31-3436696
Received: January 28, 2014
Revised: April 25, 2014
Accepted: June 10, 2014
Published online: August 15, 2014
Revised: April 25, 2014
Accepted: June 10, 2014
Published online: August 15, 2014
Core Tip
Core tip: The present project was performed to compare a possible relation between Helicobacter pylori (H. pylori) and the oxygen- and nitrogen radical system in humans. Expression of inducible nitric oxide syntase, myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase was upregulted in the antrum of the group with H. pylori infection. Regarding nitrotyrosine formation, Western blot did not show any significant increase or decrease compared to controls. The present study illustrates the complex picture of the oxidative stress in relation to H. pylori infection. The present study supports the theory of an H. pylori related inhibition of the enzymes involved in the oxy- and/or nitro- radical formation pathway.