Published online Jan 22, 2022. doi: 10.4291/wjgp.v13.i1.15
Peer-review started: March 8, 2021
First decision: May 3, 2021
Revised: May 23, 2021
Accepted: November 13, 2021
Article in press: November 13, 2021
Published online: January 22, 2022
Core Tip: Radical resection is the most effective treatment for gastrointestinal stromal tumors, but there are other options including minimally invasive surgery and multidisciplinary treatment, which involves the use of neoadjuvant therapy in consideration of tumor size and location. Combination with tyrosine kinase inhibitors is important for maximizing the therapeutic effect of surgery. To predict the effect, it is important to examine the presence of tumor mutations, including type, location of the mutation, and molecular subtype. We herein discuss the current treatment strategies for gastrointestinal stromal tumors and promising treatments based on clinical trials.