Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Nov 13, 2019; 10(4): 42-53
Published online Nov 13, 2019. doi: 10.4291/wjgp.v10.i4.42
Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula
James B Haddow, Omar Musbahi, Thomas T MacDonald, Charles H Knowles
James B Haddow, Omar Musbahi, Thomas T MacDonald, Charles H Knowles, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 5AT, United Kingdom
Author contributions: Haddow J MacDonald TT and Knowles CH conceived and designed the study; Haddow J recruited the patients and acquired the data; Haddow J and Knowles CH acquired the specimens; Haddow J and Musbahi O performed the laboratory measurements and inputted the data; Haddow J and Knowles CH analysed the data; Haddow J, Knowles CH and MacDonald TT interpreted the data; Haddow J wrote the article; Haddow J, Musbahi O, MacDonald TT and Knowles CH edited, reviewed and approved the final article.
Supported by Bowel and Cancer Research charity, No. MMBG1J3R.
Institutional review board statement: The study was reviewed and approved by Queen’s Square Research Ethics Committee.
Informed consent statement: Informed consent was obtained from the patients.
Conflict-of-interest statement: The authors have no conflicts of interest.
Data sharing statement: Any researcher wishing to access the data or materials referred to within this paper are welcome to contact the corresponding author.
STROBE statement: The STROBE guidelines were followed for reporting.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: James B Haddow, FRCS, MD, Academic Fellow, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, National Bowel Research Centre, 1st Floor Abernethy Building, 2 Newark St, Whitechapel, London E1 2AT, United Kingdom. james.haddow@icloud.com
Telephone: +44-20-78825555
Received: April 30, 2019
Peer-review started: April 30, 2019
First decision: September 6, 2019
Revised: September 28, 2019
Accepted: October 18, 2019
Article in press: October 18, 2019
Published online: November 13, 2019
Core Tip

Core tip: We systematically compared idiopathic and Crohn’s perianal fistulae, but did not find major differences in their cytokine and phosphoprotein profiles. Although more research is needed, our results support the thesis that biological agents effective in Crohn’s disease-related perianal fistulae may also have a role in selected surgically-intractable idiopathic perianal fistulae.