Review
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World J Gastrointest Pathophysiol. Aug 15, 2014; 5(3): 304-321
Published online Aug 15, 2014. doi: 10.4291/wjgp.v5.i3.304
Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature
Patricia Sarlos, Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Andras Javorhazy, Bela Melegh
Patricia Sarlos, 1st Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary
Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary
Erzsebet Kovesdi, Lili Magyari, Zsolt Banfai, Andras Szabo, Bela Melegh, Szentagothai Research Centre, 7624 Pecs, Hungary
Andras Javorhazy, Department of Urology, University of Pecs, 7621 Pecs, Hungary
Author contributions: Sarlos P, Kovesdi E, Magyari L, Banfai Z, Szabo A, Javorhazy A, Melegh B contributed equally to this work; Melegh B conceived the study; Kovesdi E, Magyari L, Banfai Z wrote the genetic part of the study; Sarlos P, Szabo A wrote the clinical section of the review; Javorhazy A prepared the Figure.
Supported by The grant of the Hungarian Science Foundation, No. OTKA K103983
Correspondence to: Bela Melegh, MD, PhD, DSc, Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary. bela.melegh@aok.pte.hu
Telephone: +36-72-536427 Fax: +36-72-536032
Received: January 28, 2014
Revised: March 19, 2014
Accepted: July 12, 2014
Published online: August 15, 2014
Abstract

Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammation-related genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.

Keywords: Ulcerative colitis, Inflammatory factors, Genes, Polymorphisms, Susceptibility

Core tip: Ulcerative colitis (UC) is a disorder of the idiopathic and chronic inflammation of the colonic mucosa. Several genetics factors influence the development of the disease, especially interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes. In this review we collected the current literature on PubMed Database about those genetic markers that are associated with UC, we focused on the following terminology: UC, inflammation, genes, polymorphisms, susceptibility.