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World J Gastrointest Pathophysiol. Jun 15, 2010; 1(2): 63-68
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.63
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.63
Biogenic amines serotonin and dopamine regulate cholangiocyte hyperplastic and neoplastic growth
Gabriel A Frampton, Huang Li, Akimuddin Mohamad, Department of Medicine, Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, United States
Huang Li, Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Jonathan Ramirez, Sharon DeMorrow, Digestive Disease Research Center, Department of Medicine, Scott and White Hospital, Temple, TX 76504, United States
Author contributions: Frampton GA, Li H, Ramirez J and Mohamad A all performed literature searches, contributed conceptually to the work and made editorial corrections; and DeMorrow S contributed to the concepts and drafting of this review.
Supported by an NIH K01 Grant Award (DK078532) to Dr. DeMorrow
Correspondence to: Sharon DeMorrow, PhD, Department of Internal Medicine, Scott and White Hospital and Texas A&M Health Science Center, Medical Research Building, 702 SW H.K. Dodgen Loop, Temple, TX 76504, United States. demorrow@medicine.tamhsc.edu
Telephone: +1-254-7246240 Fax: +1-254-7248070
Received: February 9, 2010
Revised: March 26, 2010
Accepted: April 2, 2010
Published online: June 15, 2010
Revised: March 26, 2010
Accepted: April 2, 2010
Published online: June 15, 2010
Abstract
Biogenic amines, such as serotonin and dopamine, regulate a multitude of cellular responses. A great deal of effort has been invested into understanding the effects of these molecules and their corresponding receptor systems on cholangiocyte and cholangiocarcinoma secretion, apoptosis and growth. This review summarizes the results of these efforts and highlights the importance of these regulatory molecules on the physiology and pathophysiology of cholangiocytes. Specifically we have focused on the recent findings into the effects of serotonin and dopamine on cholangiocyte hyperplasia and neoplastic growth.
Keywords: Ductal secretion, Cholangiocarcinoma, Monoamine oxidase A, Tryptophan hydroxylase 1, Tyrosine hydroxylase