David Aramburu Núñez, Antonio Lopez Medina, Francisco Salvador Gomez, Department of Medical Physics and Radiological Protection, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain
David Aramburu Núñez, Abhay Dave, Ramesh Paudyal, Joseph O Deasy, Amita Shukla-Dave, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, United States
David Aramburu Núñez, Alfonso Calzado, Department of Radiology, Complutense University, 28040 Madrid, Spain
Moisés Mera Iglesias, Department of Medical Physics, Oncoserv, Santiago de los Caballeros 51000, Dominican Republic
Vaios Hatzoglou, Amita Shukla-Dave, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, United States
Victor M Muñoz, Department of Radiation Oncology, Galaria - Meixoeiro, University Hospital Complex of Vigo, 36200 Vigo, Spain
Author contributions: Aramburu Núñez D, Lopez Medina A and Shukla-Dave A designed the study, performed MRI research, analyzed the data and wrote the paper; Dave A and Paudyal R analyzed the data and reviewed the paper; Mera Iglesias M and Salvador Gomez F performed MRI research and provided software support; Muñoz VM enrolled patients, and performed clinical assessment as per standard of care; Hatzoglou V performed the radiologic assessment; Calzado A and Deasy JO provided support.
Supported by The National Health Institute of Spain: ISCIII Grant PI11/02035 and DTS14/00188; BIOCAPS project (FP7/REGPOT-2012-2013.1), No. 316265; MSKCC internal IMRAS grant; and in part through the NIH/NCI Cancer Center, No. P30 CA008748.
Institutional review board statement: Six patients were enrolled in the Meixoeiro Hospital of Vigo Research Protocol entitled “Radioterapia adaptativa y predicción de la respuesta tumoral basadas en estudios funcionales de RM y PET/CT en cáncer de cabeza y cuello” (ISCIII Grant PI1102035).
Informed consent statement: All patients gave informed consent for their participation in the study approved by the hospital, which was conducted in accordance with the Declaration of Helsinki.
Conflict-of-interest statement: All authors have no conflicts of interest with regard to this manuscript.
Data sharing statement: Upon formal request and with proper motivation, all original data in anonymized format is available from the corresponding author for local inspection, but cannot leave Meixoeiro Hospital of Vigo and Memorial Sloan Kettering Cancer Center.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amita Shukla-Dave, PhD, Director Quantitative Imaging, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. firstname.lastname@example.org
Telephone: +1-212-6393184 Fax: +1-212-7173010
Received: August 17, 2016
Peer-review started: August 18, 2016
First decision: October 21, 2016
Revised: October 29, 2016
Accepted: November 21, 2016
Article in press: November 23, 2016
Published online: January 28, 2017