Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Sep 28, 2016; 8(9): 799-808
Published online Sep 28, 2016. doi: 10.4329/wjr.v8.i9.799
Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine
Jun Toyohara
Jun Toyohara, Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
Author contributions: Toyohara J generated the figures and wrote the manuscript.
Supported by A Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, No. (B) 25293271.
Conflict-of-interest statement: The author declares that he has no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Jun Toyohara, PhD, Theme Leader, Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Telephone: +81-3-39643210 Fax: +81-3-39641148
Received: February 25, 2016
Peer-review started: February 27, 2016
First decision: May 13, 2016
Revised: June 12, 2016
Accepted: July 29, 2016
Article in press: August 1, 2016
Published online: September 28, 2016
Core Tip

Core tip: There is a continuous demand to measure in situ DNA synthesis rates in living human cancer. The thymidine derivative 4′-[methyl-11C] thiothymidine (11C-4DST) has the potential to visualize in vivo DNA synthesis rates with positron emission tomography (PET). To confirm whether 11C-4DST is a valid DNA synthesis marker, clinical and basic research is being conducted at several PET centers in Japan, European Union, and the United States. This mini-review summarizes the progress of recent studies involving the in vivo imaging of cancer DNA synthesis using 11C-4DST PET.