Published online Sep 28, 2016. doi: 10.4329/wjr.v8.i9.799
Peer-review started: February 27, 2016
First decision: May 13, 2016
Revised: June 12, 2016
Accepted: July 29, 2016
Article in press: August 1, 2016
Published online: September 28, 2016
Core tip: There is a continuous demand to measure in situ DNA synthesis rates in living human cancer. The thymidine derivative 4′-[methyl-11C] thiothymidine (11C-4DST) has the potential to visualize in vivo DNA synthesis rates with positron emission tomography (PET). To confirm whether 11C-4DST is a valid DNA synthesis marker, clinical and basic research is being conducted at several PET centers in Japan, European Union, and the United States. This mini-review summarizes the progress of recent studies involving the in vivo imaging of cancer DNA synthesis using 11C-4DST PET.