Published online Nov 28, 2016. doi: 10.4329/wjr.v8.i11.857
Peer-review started: June 6, 2016
First decision: July 26, 2016
Revised: October 11, 2016
Accepted: October 22, 2016
Article in press: October 23, 2016
Published online: November 28, 2016
Core tip: The current application of diffusion-weighted imaging (DWI) is reviewed. DWI has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. However, some limitations remain in terms of lesion characterization and fibrosis detection. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis.