Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2016; 8(11): 851-856
Published online Nov 28, 2016. doi: 10.4329/wjr.v8.i11.851
Metabolic positron emission tomography imaging of cancer: Pairing lipid metabolism with glycolysis
Sandi A Kwee, John Lim
Sandi A Kwee, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, United States
Sandi A Kwee, John Lim, Hamamatsu/Queen’s PET Imaging Center, the Queen’s Medical Center, Honolulu, HI 96813, United States
Author contributions: Kwee SA and Lim J contributed to conception, data gathering, analysis, writing, and final approval of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sandi A Kwee, MD, PhD, Hamamatsu/Queen’s PET Imaging Center, the Queen’s Medical Center, 1301 Punchbowl St., Honolulu, HI 96813, United States. kwee@hawaii.edu
Telephone: +1-808-6915466 Fax: +1-808-6917813
Received: August 18, 2016
Peer-review started: August 22, 2016
First decision: September 6, 2016
Revised: September 20, 2016
Accepted: October 17, 2016
Article in press: October 18, 2016
Published online: November 28, 2016
Core Tip

Core tip: Positron emission tomography (PET) imaging using multiple distinct metabolic tracers could eventually play a greater role in supporting precision medicine as efforts to develop small-molecule metabolic pathway inhibitors are coming to fruition. To prepare for this advent, clinical and translational studies of metabolic PET tracers must go beyond simply estimating tracer diagnostic utility, and aim to uncover potential therapeutic avenues associated with metabolic alterations in cancer.