Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Feb 28, 2015; 7(2): 52-56
Published online Feb 28, 2015. doi: 10.4329/wjr.v7.i2.52
Transcranial Doppler screening in sickle cell disease: The implications of using peak systolic criteria
Lena N Naffaa, Yasmeen K Tandon, Neville Irani
Lena N Naffaa, Department of Radiology, Akron Children’s Hospital, Akron, OH 44308, United States
Yasmeen K Tandon, Department of Radiology, Case Western Reserve University-Metro Health Medical Center, Cleveland, OH 44109, United States
Neville Irani, Radiology, Kansas University Medical Center, Kansas City, KS 66160, United States
Author contributions: Naffaa LN, Tandon YK and Irani N contributed equally to this work; Naffaa LN and Irani N interpreted images in this study; Naffaa LN, Tandon YK and Irani N collected the patient’s clinical data; Naffaa LN, Tandon YK and Irani N analyzed the data and wrote the paper; Naffaa LN, Tandon YK and Irani N gave final approval of the version to be published.
Ethics approval: The study was reviewed and approved by the Akron Children’s Hospital Institutional Review Board.
Informed consent: Informed consent was not required for this study as it was a retrospective study and the presented data are anonymized and risk of identification is low.
Conflict-of-interest: The authors have no conflicts of interest to declare.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Lena N Naffaa, MD, Radiologist, Department of Radiology, Akron Children’s Hospital, 1 Perkins Square, Akron, OH 44308, United States.
Telephone: +1-330-5438275 Fax: +1-330-5433760
Received: October 14, 2014
Peer-review started: October 15, 2014
First decision: December 17, 2014
Revised: December 25, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: February 28, 2015
Core Tip

Core tip: To the best of our knowledge, there has been no direct comparison between peak systolic velocity and time average maximum mean velocity in their ability to predict abnormalities on magnetic resonance imaging (MRI)/magnetic resonance angiogram in children with sickle cell disease. With the growing clinical use of MR Angiography to assess sickle cell patients, the sensitivity of Trans Cranial Doppler (TCD) should be maximized if it is to maintain its role as a screening test in the sickle cell population. Based on the data obtained at our institution and using the assumption that the best screening test is the one with the highest sensitivity, the peak systolic velocity could be the measurement of choice for TCD screening.