Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Nov 28, 2015; 7(11): 394-404
Published online Nov 28, 2015. doi: 10.4329/wjr.v7.i11.394
Magnetic resonance imaging in assessment of stress urinary incontinence in women: Parameters differentiating urethral hypermobility and intrinsic sphincter deficiency
Katarzyna Jadwiga Macura, Richard Eugene Thompson, David Alan Bluemke, Rene Genadry
Katarzyna Jadwiga Macura, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, United States
Richard Eugene Thompson, Johns Hopkins Biostatistics Center, Baltimore, MD 21205, United States
David Alan Bluemke, National Institutes of Health Clinical Center, Bethesda, MD 20892, United States
Rene Genadry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United States
Author contributions: Macura KJ, Bluemke DA and Genadry R contributed to the design of the study, acquisition of data, and interpretation of data; Thompson RE performed statistical analysis of data; Macura KJ and Genadry R drafted the article; Macura KJ, Thompson RE, Bluemke DA and Genadry R made critical review of the content of the manuscript and approved the final version of the article.
Supported by The Radiological Society of North America and the Society of Computed Body Tomography and Magnetic Resonance.
Institutional review board statement: The study was approved by the Johns Hopkins University Institutional Review Board.
Informed consent statement: The study was compliant with the Health Insurance Portability and Accountability Act. Study-specific written consent was obtained from all subjects.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Data sharing statement: Participants did not give informed consent for data sharing and no additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Katarzyna Jadwiga Macura, MD, PhD, Professor of Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N. Caroline Street, JHOC 3140C, Baltimore, MD 21287, United States.
Telephone: +1-410-9555391 Fax: +1-410-9557699
Received: June 30, 2015
Peer-review started: July 5, 2015
First decision: July 31, 2015
Revised: August 22, 2015
Accepted: September 29, 2015
Article in press: September 30, 2015
Published online: November 28, 2015
Core Tip

Core tip: Magnetic resonance imaging (MRI) allows visualization of the female urethra and periurethral tissues relevant to stress urinary incontinence (SUI). The role of MRI in the specific diagnosis of SUI caused by urethral hypermobility (UH) and/or intrinsic sphincter deficiency (ISD) has not been documented. The purpose of this pilot study was to define the MRI parameters differentiating UH and ISD types of incontinence, and assess their ability to predict the type of SUI when urodynamic (UD) results are used as a reference standard. Bladder neck funneling and length of the suprapubic urethral sphincter on MRI were significantly associated with the type of incontinence on UDs.