Published online Sep 28, 2014. doi: 10.4329/wjr.v6.i9.708
Revised: July 1, 2014
Accepted: July 15, 2014
Published online: September 28, 2014
Core tip: Radiation pneumonitis (RP) is one of the most common toxicities after stereotactic body radiation therapy (SBRT). Although most RP is Grade 1 or 2 and either asymptomatic or manageable, a few cases are severe and there is a risk for mortality. A dose-effect relationship has been demonstrated that can be used for treatment planning. Other prognostic indicators of severe radiation pneumonitis after SBRT are an interstitial pneumonitis shadow on computed tomography scan and high levels of serum Krebs von den Lungen-6 and surfactant protein D before treatment.