Published online Sep 28, 2014. doi: 10.4329/wjr.v6.i9.657
Revised: April 9, 2014
Accepted: July 15, 2014
Published online: September 28, 2014
Core tip: Gaucher disease is the most common lysosomal storage disease resulting from accumulation of undegraded glucosylceramide in the reticuloendothelial system of the bone marrow, spleen and liver. Although affecting all three organs, the bone manifestations lead to the most debilitation. Visceral and bone marrow infiltration respond to enzyme replacement therapy however, the bone marrow response typically takes much longer.