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World J Radiol. Sep 28, 2014; 6(9): 643-656
Published online Sep 28, 2014. doi: 10.4329/wjr.v6.i9.643
From histology to micro-CT: Measuring and modeling resorption cavities and their relation to bone competence
Jef Vanderoost, G Harry van Lenthe
Jef Vanderoost, G Harry van Lenthe, Biomechanics Section, Department of Mechanical Engineering, KU Leuven, 3001 Leuven, Belgium
Author contributions: Vanderoost J and van Lenthe GH solely contributed to this paper.
Correspondence to: G Harry van Lenthe, PhD, Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Celestijnenlaan 300c b2419, 3001 Leuven, Belgium.
Telephone: +32-16-322595 Fax: +32-16-322595
Received: December 22, 2013
Revised: April 22, 2014
Accepted: July 25, 2014
Published online: September 28, 2014
Core Tip

Core tip: Osteoclasts create bone deficits by eroding resorption cavities. Understanding how these cavities impair the mechanical quality of the bone is relevant in both in healthy bone and in metabolic bone diseases. However, the current knowledge of their dimensions and effect on bone competence remains limited. Until recently cavity dimensions were estimated from two-dimensional measures (histology), hence, careful interpretation was necessary. With new imaging techniques quantifying resorption cavities in three-dimensional becomes feasible. Computational models have shown that resorption cavities affect bone competence. The use of high-resolution representations and parametric descriptions could improve the quantitative fidelity of these models.