Published online Jul 28, 2014. doi: 10.4329/wjr.v6.i7.511
Revised: May 23, 2014
Accepted: June 18, 2014
Published online: July 28, 2014
Core tip: Aicardi syndrome is a rare genetic disease characterized by a characteristic classical trio of neurological clinical abnormalities (spasms), agenesis of the corpus callosum and ophthalmological abnormalities (chorioretinal lacunae). The diagnosis can be suspected by prenatal ultrasound with color Doppler identifying the agenesis of the corpus callosum. Usually, the diagnosis is confirmed in the neonate period by transfontanellar ultrasound and ophthalmological examination. Tranfontanellar ultrasound is a cheap and affordable method, with similar accuracy of magnetic resonance imaging.