Published online Dec 28, 2013. doi: 10.4329/wjr.v5.i12.460
Revised: October 29, 2013
Accepted: November 18, 2013
Published online: December 28, 2013
Core tip: Abnormal focal uptake without corresponding anatomic abnormality on the integrated computer tomography (CT) imaging poses a dilemma in interpretation of whole-body fluorodeoxyglucose positron emission tomography (PET)-CT imaging. Most of the PET hot spots with the absence of CT lesions or abnormalities are artefactual or secondary to benign etiologies, but some may represent early staged or small sized neoplasm or metastases especially in the gastrointestinal tract and skeletons. Caution should be exercised to simply diagnose a pathology based on the presence of the uptake only, or exclude the disease based on the absence of anatomic abnormality.