Published online Oct 28, 2013. doi: 10.4329/wjr.v5.i10.356
Revised: September 10, 2013
Accepted: September 18, 2013
Published online: October 28, 2013
Core tip: The aim of this paper is to review sonographic markers associated with the most frequent fetal abnormalities (chromosomal anomalies, cardiac defects, skeletal dysplasia) and their sensitivity in prenatal diagnosis. Fetal malformations are very frequent in industrialized countries and the only effective approach for prenatal screening is currently represented by an ultrasound scan. Early detection of abnormalities can optimize pregnancy management and childbirth timing, give the possibility of performing simpler procedures for termination of pregnancy in those patients in whom findings are abnormal, and plan therapeutic treatment of objectively selected diseased fetuses.