Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Jun 28, 2025; 17(6): 106438
Published online Jun 28, 2025. doi: 10.4329/wjr.v17.i6.106438
Factors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence?
Cornelius J Fernandez, Vijaya Lakshmi, Abul Bashar M Kamrul-Hasan, Joseph M Pappachan
Cornelius J Fernandez, Department of Endocrinology and Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston PE21 9QS, Lincolnshire, United Kingdom
Vijaya Lakshmi, Department of General Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal 576104, Karnātaka, India
Abul Bashar M Kamrul-Hasan, Department of Endocrinology, Mymensingh Medical College, Mymensingh 2200, Bangladesh
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom
Joseph M Pappachan, Department of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, India
Co-first authors: Cornelius J Fernandez and Vijaya Lakshmi.
Author contributions: Fernandez CJ, Kamrul-Hasan ABM, and Lakshmi V contributed to the interpretation of relevant literature; Fernandez CJ, Lakshmi V, and Pappachan JM participated in the literature search; Fernandez CJ and Lakshmi V substantially contributed to article drafting, created the figures, and revision and share the first authorship; Kamrul-Hasan ABM conceived the idea, contributed to the revision of the paper; Pappachan JM contributed to the conceptualisation and design of the article, revision and overall supervision of the article drafting process. All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joseph M Pappachan, MD, FRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, Oxford Road, Manchester M15 6BH, United Kingdom. drpappachan@yahoo.co.in
Received: February 26, 2025
Revised: April 18, 2025
Accepted: May 21, 2025
Published online: June 28, 2025
Processing time: 120 Days and 18.3 Hours
Core Tip

Core Tip: Transsphenoidal surgery is the most effective treatment for acromegaly. Alone, it could achieve a remission rate of 73%. However, when followed by medical therapy, the remission rates could reach 87%. The biochemical remission rates following surgery and medical therapy are highly variable depending on various clinical, biochemical, radiological, histopathological and genetic parameters. Earlier studies have identified tumor size, tumor invasion, T2-weighted hyperintensity, granulation, and pretreatment growth hormone and/or insulin-like growth factor 1 levels as important prognostic markers. A study published by Alvarez et al noted that preoperative pituitary neuroendocrine tumor volume could predict postoperative remission.