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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Aug 28, 2020; 12(8): 184-194
Published online Aug 28, 2020. doi: 10.4329/wjr.v12.i8.184
Published online Aug 28, 2020. doi: 10.4329/wjr.v12.i8.184
Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography
Sharon Hannah Barazani, Renata Pyzik, Zahi A Fayad, Venkatesh Mani, Department of Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Wei-Wei Chi, Yousaf Ali, Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Helena Chang, Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Adam Jacobi, Zahi A Fayad, Venkatesh Mani, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Tom O’Donnell, Siemens Healthineers, Erlangen 91052, Germany
Author contributions: Barazani SH prepared the first draft of the manuscript which was then revised critically for content by all authors; Barazani SH, Chi WW, Pyzik R recruited subjects and acquired data; Barazani SH, Chi WW, Pyzik R, Chang H and Mani V analyzed the data; Chi WW, Chang H, Jacobi A, Fayad ZA and Mani V interpreted the data; Chi WW, Jacobi A and Ali Y were responsible for patient safety monitoring; Jacobi A, Fayad ZA, Ali Y and Mani V conceived and designed the study; Mani V will be responsible for accuracy, and integrity of the data.
Institutional review board statement: The study was reviewed and approved by the Icahn School of Medicine at Mount Sinai, Mount Sinai St, Luke’s, Mount Sinai West.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors have any conflicts of interest with regards to the study.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Venkatesh Mani, PhD, Associate Professor, Department of Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States. venkatesh.mani@mssm.edu
Received: March 9, 2020
Peer-review started: March 9, 2020
First decision: April 25, 2020
Revised: June 16, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: August 28, 2020
Peer-review started: March 9, 2020
First decision: April 25, 2020
Revised: June 16, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: August 28, 2020
Core Tip
Core tip: There is increasing evidence that gout is an independent risk factor for cardiovascular disease progression. In hyperuricemic individuals, monosodium urate may be deposited within the vessel wall and possibly lead to an inflammatory cascade. We examine if dual energy computed tomography can quantify monosodium urate depositions in the vasculature of gout patients, and measure deposits volumetrically to see if they are higher in these individuals compared to healthy controls. The study shows that dual energy computed tomography can detect vascular deposits and that gout patients possibly have increased deposition, and corroborates recent studies that show the presence of vascular deposition.