Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Effects of muscle fiber orientation to main magnetic field on muscle metabolite profiles for magnetic resonance spectroscopy acquisition
Duanghathai Pasanta, Tipparat Kongseha, Suchart Kothan, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
Author contributions: Pasanta D, Kongseha T and Kothan S contributed to the conception and design of this study; as well as the acquisition, analysis, and interpretation of all data. These authors wrote drafts of the article and made critical revisions related to the intellectual content of the manuscript and approved the final version of the article for publication.
Supported by Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand .
Conflict-of-interest statement: All authors have no conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Suchart Kothan, PhD, Associate Professor, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Rd., Sripoom, Chiang Mai 50200, Thailand. suchart.kothan@cmu.ac.th
Telephone: +66-53-939213 Fax: +66-53-939207
Received: August 6, 2018
Peer-review started: August 7, 2018
First decision: October 16, 2018
Revised: November 14, 2018
Accepted: January 9, 2019
Article in press: January 10, 2019
Published online: January 28, 2019
Peer-review started: August 7, 2018
First decision: October 16, 2018
Revised: November 14, 2018
Accepted: January 9, 2019
Article in press: January 10, 2019
Published online: January 28, 2019
Core Tip
Core tip: Proton magnetic resonance spectroscopy (1H MRS) is a technique that is widely used for intramyocellular lipids and extramyocellular lipids quantification in muscles, as evidenced in various studies. However, different muscle positions can potentially lead to inconsistency in metabolite quantification and can also impede interpretation of data, which can lead to misinformation. This study reveals that the muscle orientation at 0°, 30°, 60°, and 90° to the main magnetic field significantly affects the metabolite profile and quantification. The metabolite profile changes due to the muscle fiber orientation demonstrate that the positioning potentially causes inaccuracy in 1H-MRS spectrum analysis.