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World J Radiol. Nov 28, 2014; 6(11): 874-880
Published online Nov 28, 2014. doi: 10.4329/wjr.v6.i11.874
Impact of dose calculation algorithm on radiation therapy
Wen-Zhou Chen, Ying Xiao, Jun Li
Wen-Zhou Chen, Ying Xiao, Jun Li, Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: All three authors contributed to manuscript preparation
Supported by In part, under a grant with the Pennsylvania Department of Health
Correspondence to: Jun Li, PhD, Department of Radiation Oncology, Thomas Jefferson University, 111 South 11th St., Philadelphia, PA 19107, United States. jun.li@jefferson.edu
Telephone: +1-215-9557945 Fax: +1-215-5032386
Received: May 8, 2014
Revised: August 4, 2014
Accepted: September 23, 2014
Published online: November 28, 2014
Abstract

The quality of radiation therapy depends on the ability to maximize the tumor control probability while minimize the normal tissue complication probability. Both of these two quantities are directly related to the accuracy of dose distributions calculated by treatment planning systems. The commonly used dose calculation algorithms in the treatment planning systems are reviewed in this work. The accuracy comparisons among these algorithms are illustrated by summarizing the highly cited research papers on this topic. Further, the correlation between the algorithms and tumor control probability/normal tissue complication probability values are manifested by several recent studies from different groups. All the cases demonstrate that dose calculation algorithms play a vital role in radiation therapy.

Keywords: Dose calculation, Algorithm, Radiation therapy, Tumor control probability, Normal tissue complication probability

Core tip: This paper is a review of the impact of current commercial dose calculation algorithms on radiation therapy, with a focus on discussing the impact on tumor control probability and normal tissue complication probability.