Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Radiol. Jun 28, 2012; 4(6): 247-252
Published online Jun 28, 2012. doi: 10.4329/wjr.v4.i6.247
Ultrasound- and MR-guided focused ultrasound surgery for prostate cancer
Chiara Zini, Elisabeth Hipp, Stephen Thomas, Alessandro Napoli, Carlo Catalano, Aytekin Oto
Chiara Zini, Alessandro Napoli, Carlo Catalano, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161 Rome, Italy
Elisabeth Hipp, Stephen Thomas, Aytekin Oto, Department of Radiology, The University of Chicago, Chicago, IL 60637, United States
Author contributions: Zini C and Oto A contributed to data collection, analysis, manuscript preparation, and the decision to submit for publication; Hipp E, Napoli A, Thomas S and Catalano C contributed to manuscript preparation, and the decision to submit for publication.
Correspondence to: Aytekin Oto, MD, Department of Radiology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States.
Telephone: +1-773-7028553 Fax: + 1-773-7021161
Received: March 14, 2012
Revised: May 15, 2012
Accepted: May 22, 2012
Published online: June 28, 2012

Prostate cancer (PC) is one of the most frequently diagnosed cancers in men. There are a number of treatment options for PC with a different therapeutic approach between USA and Europe. Radical prostatectomy is one of the most used therapies but focal gland therapy is an emerging approach, especially for localized tumors. In this scenario, high intensity focused ultrasound (HIFU) has been incorporated in certain medical association guidelines. HIFU has been employed for about 10 years especially for localized PC. Results are promising with a 5-year biochemical survival rate ranging from 45% to 84%. Collateral events are rare and HIFU retreatment is not common. Magnetic resonance guided focused ultrasound surgery (MRgFUS) was recently presented as a method for ablation with focused ultrasound under magnetic resonance imaging guidance. It has the advantage of improved targeting and real time temperature monitoring but only a few studies have been conducted with human patients. The aim of this review is to describe the current status of HIFU and MRgFUS in the therapy of PC.

Keywords: Prostate cancer, Magnetic resonance guided focused ultrasound surgery, High intensity focused ultrasound