Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Radiol. Oct 28, 2012; 4(10): 421-430
Published online Oct 28, 2012. doi: 10.4329/wjr.v4.i10.421
Equilibrium radionuclide angiocardiography: Its usefulness in current practice and potential future applications
Deepanjan Mitra, Sandip Basu
Deepanjan Mitra, Department of Nuclear Medicine and PET CT, North City Diagnostic Centre, Kolkata 700004, India
Sandip Basu, Radiation Medicine Centre, Bhabha Atomic Research Centre, TMH Annexe, Parel, Mumbai 400012, India
Author contributions: Mitra D and Basu S contributed to concept, design, primary draft and corrections; Basu S edited the manuscipt.
Correspondence to: Dr. Sandip Basu, MBBS (Hons), DRM, DNB, MNAMS, Radiation Medicine Centre, Bhabha Atomic Research Centre, TMH Annexe, Parel, Mumbai 400012, India. drsanb@yahoo.com
Telephone: +91-93-22279718 Fax: +91-22-24157098
Received: July 2, 2012
Revised: October 2, 2012
Accepted: October 9, 2012
Published online: October 28, 2012

The routine and potential future applications of equilibrium radionuclide angiocardiography/multigated acquisition (MUGA) in clinical decision making are explored in this review. The non-invasive nature of the test, less operator dependence, lower radiation dose and ease of performing, even in ill patients, are important considerations in clinical cardiology practice. Two important routine uses of this modality in day-to-day clinical practice include the following: serial assessment of left ventricular ejection fraction (LVEF) in patients receiving cardiotoxic chemotherapy, and determination of accurate LVEF in patients with intractable heart failure. Other potential utilities of MUGA that could be translated into clinical practice include determination of regional LVEF, obtaining information about both right and left ventricle in suitable patients as a part of first pass angiocardiography, identification of diastolic dysfunction in patients with heart failure with preserved LVEF, and demonstration of dyssynchrony prior to cardiac resynchronisation, specifically by MUGA single photon emission tomography.The last two indications are particularly important and evolving at this point.

Keywords: Equilibrium radionuclide, Angiocardiography, Multigated acquisition, Left ventricular ejection fraction, Diastolic parameters, Dyssynchrony