Kayhan A, Yang C, Soylu FN, Lakadamyalı H, Sethi I, Karczmar G, Stadler W, Oto A. Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer. World J Radiol 2011; 3(10): 241-245 [PMID: 22229077 DOI: 10.4329/wjr.v3.i10.241]
Corresponding Author of This Article
Aytekin Oto, Professor of Radiology, Chief of Abdominal Imaging and Body MRI, Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637, United States. aoto@radiology.bsd.uchicago.edu
Article-Type of This Article
Brief Article
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World J Radiol. Oct 28, 2011; 3(10): 241-245 Published online Oct 28, 2011. doi: 10.4329/wjr.v3.i10.241
Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer
Arda Kayhan, Cheng Yang, Fatma Nur Soylu, Hatice Lakadamyalı, Ila Sethi, Gregory Karczmar, Walter Stadler, Aytekin Oto
Arda Kayhan, Fatma Nur Soylu, Hatice Lakadamyalı, Ila Sethi, Gregory Karczmar, Aytekin Oto, Department of Radiology, University of Chicago, Chicago, IL 60637, United States
Cheng Yang, Walter Stadler, Department of Medicine, University of Chicago, Chicago, IL 60637, United States
Gregory Karczmar, Walter Stadler, Cancer Research Center, University of Chicago, Chicago, IL 60637, United States
Author contributions: Kayhan A contributed to the interpretation of data and writing of the manuscript; Yang C performed most of the interpretation of data; Soylu FN, Lakadamyalı H and Sethi I helped with data analysis and manuscript writing; Karczmar G, Stadler W and Oto A designed the study and contributed to the writing of the manuscript.
Supported by NIH, No. P30 CA014599
Correspondence to: Aytekin Oto, Professor of Radiology, Chief of Abdominal Imaging and Body MRI, Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637, United States. aoto@radiology.bsd.uchicago.edu
Telephone: +1-773-7028553 Fax: +1-773-7021161
Received: April 28, 2011 Revised: July 19, 2011 Accepted: July 26, 2011 Published online: October 28, 2011
Abstract
AIM: To evaluate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings of bone metastasis in prostate cancer patients.
METHODS: Sixteen men with a diagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 Tesla. The mean contrast agent concentration vs time curves for bone metastasis and normal bone were calculated and Ktrans and ve values were estimated and compared.
RESULTS: An early significant enhancement (wash-out: n = 6, plateau: n = 8 and persistent: n = 2) was detected in all bone metastases (n = 16). Bone metastasis from prostate cancer showed significant enhancement and high Ktrans and ve values compared to normal bone which does not enhance in the elderly population. The mean Ktrans was 0.101/min and 0.0051/min (P < 0.001), the mean ve was 0.141 and 0.0038 (P < 0.001), for bone metastases and normal bone, respectively.
CONCLUSION: DCE-MRI and its quantitative perfusion parameters may have a role in improving the detection of skeletal metastasis in prostate cancer patients.
