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Vecchio S, Varani E, Chechi T, Balducelli M, Vecchi G, Aquilina M, Ricci Lucchi G, Dal Monte A, Margheri M. Coronary thrombus in patients undergoing primary PCI for STEMI: Prognostic significance and management. World J Cardiol 2014; 6(6): 381-392 [PMID: 24976910 DOI: 10.4330/wjc.v6.i6.381]
World J Cardiol. Jun 26, 2014; 6(6): 381-392 Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.381
Coronary thrombus in patients undergoing primary PCI for STEMI: Prognostic significance and management
Sabine Vecchio, Elisabetta Varani, Tania Chechi, Marco Balducelli, Giuseppe Vecchi, Matteo Aquilina, Giulia Ricci Lucchi, Alessandro Dal Monte, Massimo Margheri
Sabine Vecchio, Elisabetta Varani, Marco Balducelli, Giuseppe Vecchi, Matteo Aquilina, Giulia Ricci Lucchi, Alessandro Dal Monte, Massimo Margheri, Division of Cardiology, Cardiac Catheterization Laboratory, Santa Maria Delle Croci Hospital, 48121 Ravenna, Italy
Tania Chechi, Division of Cardiology, Santa Maria Annunziata Hospital, 50100 Firenze, Italy
Author contributions: Vecchio S, Varani E, Chechi T and Balducelli M wrote the manuscript; Vecchi G, Aquilina M, Ricci Lucchi G, Dal Monte A and Margheri M revised the manuscript critically for important intellectual content.
Correspondence to: Sabine Vecchio, MD, Division of Cardiology, Cardiac Catheterization Laboratory, Santa Maria Delle Croci Hospital, Viale Randi n°5, 48121 Ravenna, Italy. sabinevecchio@gmail.com
Telephone: +39-0544-285745 Fax: +39-0544-285745
Received: December 7, 2013 Revised: April 3, 2014 Accepted: April 11, 2014 Published online: June 26, 2014 Processing time: 200 Days and 14.9 Hours
Core Tip
Core tip: Intracoronary thrombosis, is the basic pathophysiologic event in acute ST-elevation myocardial infarction (STEMI), and thrombi are very frequently detected in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Thrombus burden and components are important determinants of prognosis in STEMI, being well-known risk factors for long-term adverse cardiovascular events, distal embolization and stent thrombosis. As a result, percutaneous management of lesions with a consistent thrombotic burden is still challenging in the setting of PPCI for STEMI. Therefore, several pharmacological and interventional strategies, such as thrombectomy have been developed in order to improve PPCI’s safety and efficacy, by reducing thrombus burden.
