Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2025; 17(6): 106717
Published online Jun 26, 2025. doi: 10.4330/wjc.v17.i6.106717
Beyond initial recovery: Heart failure with transient vs sustained improvement in left ventricular ejection fraction
Rasha Kaddoura, Ammar Chapra, Jassim Shah, Mohamed Izham, Rajvir Singh, Haisam Alsadi, Maha Al-Amri, Tahseen Hamamyh, Manar Fallouh, Farras Elasad, Mohamed Abdelghani, Sumaya Alsaadi Alyafei, Amr Badr, Ashfaq Patel
Rasha Kaddoura, Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha 3050, Qatar
Ammar Chapra, Jassim Shah, Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha 3050, Qatar
Mohamed Izham, Department of Clinical Pharmacy and Practice College of Pharmacy, QU Health Sector, Qatar University, Doha 2713, Qatar
Rajvir Singh, Department of Cardiology Research, Heart Hospital, Hamad Medical Corporation, Doha 3050, Qatar
Haisam Alsadi, Tahseen Hamamyh, Manar Fallouh, Farras Elasad, Mohamed Abdelghani, Amr Badr, Ashfaq Patel, Department of Cardiology, Hamad Medical Corporation, Doha 3050, Qatar
Maha Al-Amri, Sumaya Alsaadi Alyafei, Department of Pharmacy, Hamad Medical Corporation, Doha 3050, Qatar
Co-corresponding authors: Rasha Kaddoura and Ammar Chapra.
Author contributions: Kaddoura R, Chapra A, Shah J, Izham M, Singh R, Alsadi H, Al-Amri M, Hamamyh T, Fallouh M, Elasad F, Abdelghani M, Alsaadi Alyafei S, Badr A, and Patel A made a substantial, direct, and intellectual contribution to the work and approved it for publication; Kaddoura R and Chapra A contributed equally to this article and are the co-first authors of this manuscript; All authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Hamad Medical Corporation Medical Research Center, approval No. MRC-01-20-139.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment with verbal consent according to the usual standard of care.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rasha Kaddoura, Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Al-Rumailah, Doha 3050, Qatar. rasha.kaddoura@gmail.com
Received: March 5, 2025
Revised: April 2, 2025
Accepted: May 16, 2025
Published online: June 26, 2025
Processing time: 107 Days and 10.4 Hours
Core Tip

Core Tip: Our study reported observations from a population with heart failure in Qatar, a Middle Eastern country that is usually underrepresented in major clinical trials. This study was the first in the Middle East to characterize the clinical features and outcomes of patients with heart failure who demonstrate either sustained or temporary improvement in left ventricular ejection fraction.