Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2025; 17(6): 104832
Published online Jun 26, 2025. doi: 10.4330/wjc.v17.i6.104832
Hydrogen alleviates right ventricular hypertrophy by inhibiting ferroptosis via restoration of the Nrf2/HO-1 signaling pathway
Jun-Cai Bai, Hong-Xiao Yang, Cheng-Chuang Zhan, Lu-Qi Zhao, Jia-Ren Liu, Wei Yang
Jun-Cai Bai, Hong-Xiao Yang, Department of Cardiology, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou 450000, Henan Province, China
Jun-Cai Bai, Lu-Qi Zhao, Wei Yang, Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
Cheng-Chuang Zhan, Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
Jia-Ren Liu, Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
Co-first authors: Jun-Cai Bai and Hong-Xiao Yang.
Author contributions: Bai JC, Yang HX, and Zhan CC performed the experiments; Bai JC, Yang HX, and Zhan CC analyzed the data; Bai JC, Yang HX, Zhan CC, and Zhao LQ wrote the manuscript; Yang HX, Zhan CC, Zhao LQ, and Liu JR edited the manuscript; Liu JR and Yang HX critically revised the manuscript; Yang W designed the study and is the corresponding author. All the authors have read and approved the final manuscript. Bai JC and Yang HX contributed equally to this study.
Institutional review board statement: Institutional review board statement is not applicable to this study.
Institutional animal care and use committee statement: This study was approved by the Animal Care and Use Committee of the First Affiliated Hospital of Harbin Medical University.
Conflict-of-interest statement: The authors have nothing to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Data sharing statement: The data for this study can be obtained by contacting the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Yang, MD, Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan Street, Harbin 150000, Heilongjiang Province, China. weiyangyangwei@yeah.net
Received: January 8, 2025
Revised: February 26, 2025
Accepted: May 13, 2025
Published online: June 26, 2025
Processing time: 163 Days and 11.8 Hours
Core Tip

Core Tip: This study explored the protective effects of hydrogen (H2) on right ventricular hypertrophy (RVH) both in vivo and in vitro. The results revealed that H₂ inhibited ferroptosis, an iron-dependent cell death, by restoring the Nrf2/HO-1 pathway, offering new insights for treating RVH.