Prospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2021; 13(9): 503-513
Published online Sep 26, 2021. doi: 10.4330/wjc.v13.i9.503
Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease
Andrew Xanthopoulos, Konstantinos Tryposkiadis, Apostolos Dimos, Angeliki Bourazana, Alexandros Zagouras, Nikolaos Iakovis, Michail Papamichalis, Grigorios Giamouzis, George Vassilopoulos, John Skoularigis, Filippos Triposkiadis
Andrew Xanthopoulos, Apostolos Dimos, Angeliki Bourazana, Alexandros Zagouras, Nikolaos Iakovis, Michail Papamichalis, Grigorios Giamouzis, John Skoularigis, Filippos Triposkiadis, Department of Cardiology, University Hospital of Larissa, Larissa 41110, Greece
Konstantinos Tryposkiadis, Independent Biostatistician, Athens 15669, Greece
George Vassilopoulos, Department of Haematology, University of Thessaly Medical School, Larissa 41110, Greece
Author contributions: Xanthopoulos A participated in design of the study, drafted the manuscript, participated in the oversight of the study, and was involved in the data collection; Tryposkiadis K drafted the manuscript and performed the statistical analyses; Dimos A participated in design of the study, and was involved in the data collection; Bourazana A participated in the design of the study, and drafted the manuscript; Zagouras A drafted the manuscript and was involved in the data collection; Iakovis N participated in the design of the study and was involved in the data collection; Papamichalis M was involved in the data collection and drafted the manuscript; Giamouzis G participated, Vassilopoulos G, and Skoularigis J participated in the design and oversight of the study; Triposkiadis F participated in the design and oversight of the study and drafted the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the University General Hospital of Larissa, Larissa, Greece Institutional Review Board.
Informed consent statement: The need for written informed consent was waived by the ethics committee due to the observational nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interest regarding the present work
Data sharing statement: No additional data are available
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrew Xanthopoulos, FACC, MD, PhD, Consultant Physician-Scientist, Department of Cardiology, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. andrewvxanth@gmail.com
Received: March 6, 2021
Peer-review started: March 6, 2021
First decision: March 31, 2021
Revised: June 22, 2021
Accepted: August 4, 2021
Article in press: August 4, 2021
Published online: September 26, 2021
Core Tip

Core Tip: This was a prospective observational study with 204 consecutive elderly hospitalized patients seeking to evaluate the impact of cardiovascular (CV) and non-CV coexisting morbidities on red blood cell distribution width (RDW). RDW was significantly elevated and factors associated with RDW were anemia as well as CV factors associated with elevated heart rate (acutely decompensated chronic heart failure and atrial fibrillation), suggesting sympathetic overactivity.