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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2019; 11(1): 24-37
Published online Jan 26, 2019. doi: 10.4330/wjc.v11.i1.24
Published online Jan 26, 2019. doi: 10.4330/wjc.v11.i1.24
Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography
Rafael Vidal-Perez, Raúl Franco-Gutiérrez, Alberto J Pérez-Pérez, Alberto Gascón-Vázquez, Andrea López-López, Ana María Testa-Fernández, Carlos González-Juanatey, Department of Cardiology, Hospital Universitario Lucus Augusti, Lugo 27003, Spain
Virginia Franco-Gutiérrez, Department of Otolaryngology, Hospital Carmen y Severo Ochoa, Cangas del Narcea 33800, Spain
Alberto Gascón-Vázquez, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela 15782, Spain
Author contributions: All authors helped to perform the research; Vidal-Perez R contributed to manuscript writing, performing procedures, and data analysis; Franco-Gutiérrez R contributed to manuscript writing, drafting of the document, conception and design of the study, and data analysis; Pérez-Pérez AJ, Franco-Gutierrez V, Gascón-Vázquez A and López-López A contributed to manuscript writing; Testa-Fernández AM and González-Juanatey C contributed to performing procedures, drafting of the document, and conception and design of the study.
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
STROBE statement: The authors declare that the STROBE statement was followed in the article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Raúl Franco-Gutiérrez, MD, Staff Physician, Department of Cardiology, Hospital Universitario Lucus Augusti, Av/Doctor Ulises Romero nº1, Lugo 27003, Spain. raul.franco.gutierrez@sergas.es
Telephone: +34-982296738 Fax: +34-982295390
Received: September 19, 2018
Peer-review started: September 19, 2018
First decision: October 26, 2018
Revised: December 16, 2018
Accepted: December 24, 2018
Article in press: December 24, 2018
Published online: January 26, 2019
Peer-review started: September 19, 2018
First decision: October 26, 2018
Revised: December 16, 2018
Accepted: December 24, 2018
Article in press: December 24, 2018
Published online: January 26, 2019
Core Tip
Core tip: There is a controversy about obesity and coronary artery disease prognosis. Several studies suggest a greater influence of physical inactivity than that of body mass index on mortality, but there are no data addressing the influence of subclinical atherosclerosis in patients with suspected coronary artery disease submitted to a non-invasive treadmill test. Our study shows that clinical atherosclerosis in other vascular beds, such as carotid plaque presence, is a greater predictor than functional capacity. These patients could benefit from aggressive prevention measures.