Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jul 26, 2021; 13(7): 211-222
Published online Jul 26, 2021. doi: 10.4330/wjc.v13.i7.211
Effect of trabeculated myocardial mass on left ventricle global and regional functions in noncompaction cardiomyopathy
Gulsah Yildirim, Memduh Dursun, Rıfat Arslan
Gulsah Yildirim, Department of Radiology, University of Health Sciences, Istanbul Fatih Sultan Mehmet Training and Research Hospital, İstanbul 34752, Turkey
Memduh Dursun, Department of Radiology, İstanbul University School of Medicine, İstanbul 34752, Turkey
Rıfat Arslan, Department of Radiology, Istanbul University, Istanbul Faculty of Medicine, İstanbul 34752, Turkey
Author contributions: Yildirim G designed and performed the research and wrote the paper; Dursun M designed the research and supervised the report; Arslan R designed the research and contributed to the analysis.
Institutional review board statement: The study was approved by the Institutional Review Boards, No. 15.11.2016/412092.
Informed consent statement: Informed consent was obtained for the radiological study that was performed in the above-mentioned context.
Conflict-of-interest statement: We have no conflicts of interest to disclose.
Data sharing statement: Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Gulsah Yildirim, MD, Attending Doctor, Doctor, Senior Lecturer, Department of Radiology, University of Health Sciences, Istanbul Fatih Sultan Mehmet Training and Research Hospital, İçerenkoy Mah. Ataşehir, İstanbul 34752, Turkey.
Received: October 15, 2020
Peer-review started: October 15, 2020
First decision: March 31, 2021
Revised: April 12, 2021
Accepted: April 29, 2021
Article in press: April 29, 2021
Published online: July 26, 2021
Research background

The frequency of left ventricular noncompaction cardiomyopathy (LVNC) diagnosis is increasing day by day due to inadequate diagnostic criteria. In addition, the criteria used cannot determine the prognosis and stage of the disease.

Research motivation

New cardiac magnetic resonance (CMR) criteria that can be used in the diagnosis of LVNC can explain when the increased trabeculation rate in healthy individuals can be called disease. In this context, left ventricular function changes due to increased trabeculation may be a parameter.

Research objectives

In our study, it was aimed to evaluate the relationship between LV global and regional function and trabeculation increase. A new parameter that can be used in diagnosis and follow-up will increase the diagnostic specificity of LVNC.

Research methods

The distribution and ratios of trabeculations in apical, midventricular, and basal regions were examined in CMR. In addition, by using short-axis cine images, regional ejection fraction (EF) and global EF were calculated with the Simpson method in the left ventricle (LV) at apical, basal, and midventricular levels.

Research results

Global EF was correlated with apical, midventricular, and basal regional EF, but there was no significant correlation between global EF and the number of trabeculated segments or trabeculation ratio in the global LV. Also, there was no significant correlation between regional EF and the number of trabeculated segments or trabeculation ratio in all three regions.

Research conclusions

Global and regional EF changes may be new diagnostic criteria in the diagnosis of LVNC and in the follow-up of the disease.

Research perspectives

Studies on the relation of LV segmental functions with trabeculation are limited. Studies with larger cohorts and control groups should be conducted.