Published online Jul 26, 2021. doi: 10.4330/wjc.v13.i7.211
Peer-review started: October 15, 2020
First decision: March 31, 2021
Revised: April 12, 2021
Accepted: April 29, 2021
Article in press: April 29, 2021
Published online: July 26, 2021
Left ventricular (LV) noncompaction cardiomyopathy is a rare cardiomyopathic subtype that has been recognized in recent years and is being diagnosed at an increased rate. There is no consensus regarding the diagnosis of the disease, and increased trabeculation rates that meet the existing diagnostic criteria may even be present in healthy asymptomatic people. This indicates that differentiating criteria for diagnosis are needed.
To examine the increase in myocardial trabeculation and the change in left ventricular global and regional functions.
This retrospective study included 65 patients (28 females, 37 males) diagnosed with LV noncompaction cardiomyopathy who underwent cardiac magnetic resonance imaging between January 2011 and August 2016 and had a noncompacted/compacted myocardial thickness ratio of over 2.3 in more than one segment in the left ventricle. The distribution and ratios of trabeculations in apical, midventricular, and basal regions were examined in short-axis images obtained from cardiac magnetic resonance. In addition, by using short-axis cine images, regional ejection fraction (EF) and global EF were calculated using the Simpson method in the left ventricle at apical, basal, and midventricular levels.
While the number of trabeculated segments were similar at the apical (3.2 ± 1.0) and midventricular levels, a statistically significant level of involvement was not observed at the basal level (0.4 ± 0.9) (P > 0.05). The highest noncompacted/com
No global or regional relationship was observed between LV dysfunction and trabeculation rate or the number of trabeculated segments. This limits the usefulness of change in LV functions in the differentiation between normal and pathological trabeculation.
Core Tip: With the advancements in cardiac magnetic resonance, there is increased frequency of left ventricular noncompaction cardiomyopathy diagnosis; meanwhile, increased trabeculation that meet diagnostic criteria may also be observed in healthy asymptomatic individuals. This suggests the need for new diagnostic criteria of the disease. In this regard, our retrospective study investigates the impact of the number of trabeculated segments and the trabeculation ratio on regional and global left ventricular functions.