Patel N, Elsaid O, Shenoy A, Sharma A, McFarlane SI. Obesity paradox in patients undergoing coronary intervention: A review. World J Cardiol 2017; 9(9): 731-736 [PMID: 29081905 DOI: 10.4330/wjc.v9.i9.731]
Corresponding Author of This Article
Nirav Patel, MD, Department of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06001, United States. nirav.patel@hhchealth.org
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nirav Patel, Ossama Elsaid, Department of Cardiology, Hartford Hospital, Hartford, CT 06001, United States
Abhishek Shenoy, University of Virginia Health System, SUNY Downstate, Brooklyn, NY 11203, United States
Abhishek Sharma, Department of Cardiology, SUNY Downstate, Brooklyn, NY 11203, United States
Samy I McFarlane, Department of Medicine, Division of Endocrinology, SUNY Downstate, Brooklyn, NY 11203, United States
Author contributions: Patel N made substantial contribution in conception, researching literature, designing and writing this manuscript; Shenoy A helped with writing and editing the content; Elsaid O helped with editing the content; Sharma A had important contribution in conception; McFarlane SI was moderator and participated revising it critically and advice to add important intellectual material in this manuscript.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nirav Patel, MD, Department of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06001, United States. nirav.patel@hhchealth.org
Telephone: +1-860-9726000 Fax: +1-860-6963224
Received: March 13, 2017 Peer-review started: March 14, 2017 First decision: April 20, 2017 Revised: May 8, 2017 Accepted: May 18, 2017 Article in press: May 19, 2017 Published online: September 26, 2017
Abstract
There is strong relationship between obesity and cardiovascular disease including coronary artery disease (CAD). However, the literature has shown better outcomes in higher obese patients who undergo percutaneous cardiovascular interventions for CAD, a phenomenon known as the obesity paradox (OX). In this review, we performed extensive search for OX in patients undergoing percutaneous coronary intervention. We also discussed possible mechanism OX and disparities in different race and sex.
Core tip: Literatures have shown strong association between obesity and coronary artery disease (CAD). However, a phenomenon known as obesity paradox (OX) exist which means that obese patients who undergo percutaneous coronary intervention for CAD, they have better outcome compared to normal and underweight patients. New studies also suggest racial and sexual disparities in OX. Multiple mechanisms and patho-physiology have been implicated for OX. In this review, we performed literature search of OX undergoing percutaneous intervention, propose mechanism of OX and racial and sexual disparities.
