Systematic Reviews
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2017; 9(6): 553-557
Published online Jun 26, 2017. doi: 10.4330/wjc.v9.i6.553
Interferon related pericarditis: Review
Kazuaki Nishio, Tsutomu Arase, Hiroko Tada, Hideaki Tachibana
Kazuaki Nishio, Tsutomu Arase, Hiroko Tada, Hideaki Tachibana, Department of Internal Medicine, Matsui Hospital, Tokyo 145-0082, Japan
Author contributions: Nishio K drafted the manuscript, and assisted with data analysis; Arase T, Tada H and Tachibana H were involved with data collection and data analysis.
Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kazuaki Nishio, MD, Department of Internal Medicine, Matsui Hospital, 1-7-10, Ikegami, Ota-ku, Tokyo 145-0082, Japan. kazukun@jg7.so-net.ne.jp
Telephone: +81-3-37521111 Fax: +81-3-37521118
Received: November 11, 2016
Peer-review started: November 13, 2016
First decision: March 8, 2017
Revised: April 21, 2017
Accepted: May 3, 2017
Article in press: May 5, 2017
Published online: June 26, 2017
Abstract
AIM

To conduct a review of “interferon related pericarditis”.

METHODS

We searched MEDLINE, EMBASE, Cinahl, and the Cochrane Database from the earliest available date through September 2016. A search strategy using the Medical Subject Headings and text keywords “interferon” and ”pericarditis” were used.

RESULTS

Nine case reports were eligible for the present study. Six of 8 cases were women and the mean age was 43.8 ± 13.8 years with chronic hepatitis C in 6 cases, malignant melanoma in 2 cases and chronic myelogenous leukemia in 1 case. The patients complained of chest pain in 6 cases, dyspnea in 5 cases and edema in 2 cases. Pericardial friction rub was heard in 3 of 9 cases. Congestive heart failure occurred in 3 of 9 cases. Two mechanisms for pericarditis were demonstrated, one is autoimmune included lupus like syndrome in 2 cases and the other is cardio toxicity in 4 cases. Treatment of interferon related pericarditis is discontinuation of Interferon treatment. Four of 9 cases were treated with prednisone and 4 with nonsteroidal anti-inflammatory drugs.

CONCLUSION

Interferon related pericarditis still remains uncertain. Treatment of interferon related pericarditis rests mainly on early recognition and drug discontinuation. Interferon related pericarditis was treated with steroid and/or nonsteroidal anti-inflammatory drugs.

Keywords: Chronic hepatitis C, Chronic myelogeneous leukemia, Interferon, Malignant lymphoma, Pericarditis

Core tip: Interferon is considered to be one of the treatments for many diseases. However, interferon therapy is associated with side effects. Recently some reports demonstrated acute pericarditis complicating interferon therapy. Two mechanisms for pericarditis were demonstrated, one is autoimmune included lupus like syndrome and the other is cardio toxicity. However, these two mechanisms are controversial. The aim of this study is to review of “interferon related pericarditis”.