Barmore W, Patel H, Harrell S, Garcia D, Calkins Jr JB. Takotsubo cardiomyopathy: A comprehensive review. World J Cardiol 2022; 14(6): 355-362 [PMID: 35979181 DOI: 10.4330/wjc.v14.i6.355]
Corresponding Author of This Article
Walker Barmore, MD, Doctor, Department of Internal Medicine, Augusta University Medical Center, 1120 15th Street BI 5070, Augusta, GA 30912, United States. wabarmore@augusta.edu
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jun 26, 2022; 14(6): 355-362 Published online Jun 26, 2022. doi: 10.4330/wjc.v14.i6.355
Takotsubo cardiomyopathy: A comprehensive review
Walker Barmore, Himax Patel, Sean Harrell, Daniel Garcia, Joe B Calkins Jr
Walker Barmore, Himax Patel, Daniel Garcia, Department of Internal Medicine, Augusta University Medical Center, Augusta, GA 30912, United States
Sean Harrell, Joe B Calkins Jr, Department of Cardiovascular Medicine, Augusta University Medical Center, Augusta, GA 30912, United States
Author contributions: Barmore W, Patel H and Harrell S performed the majority of the writing, prepared the figures and tables; Barmore W and Patel H performed data accusation and writing; Barmore W, Patel H, Harrell S and Garcia D performed the majority of literature review; Calkins Jr JB provided the input in writing the paper; Harrell S designed the outline and coordinated the writing of the paper.
Supported bythe Gordon Chason Miller M.D. Cardiology Education Endowment Fund in the Medical College of Georgia Foundation, Inc.
Conflict-of-interest statement: The Authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Walker Barmore, MD, Doctor, Department of Internal Medicine, Augusta University Medical Center, 1120 15th Street BI 5070, Augusta, GA 30912, United States. wabarmore@augusta.edu
Received: January 24, 2022 Peer-review started: January 24, 2022 First decision: March 16, 2022 Revised: March 24, 2022 Accepted: May 25, 2022 Article in press: May 25, 2022 Published online: June 26, 2022
Abstract
Takotsubo cardiomyopathy (TCM), also known as stress cardiomyopathy, occurs in the setting of catecholamine surge from an acute stressor. This cardiomyopathy mimics acute myocardial infarction in the absence of coronary disease. The classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left ventricle. The etiology of the stressor is often physical or emotional stress, however iatrogenic causes of TCM have been reported in the literature. In our review, we discuss medications, primarily the exogenous administration of catecholamines, and a wide array of procedures with subsequent development of iatrogenic cardiomyopathy. TCM is unique in that it is transient and has favorable outcomes in most individuals. Classically, beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy; however, unique to TCM, no specific treatment is required other than temporary supportive measures as this process is transient. Additionally, no improvement in mortality or recurrence have been reported in patients on these drugs. The aim of this review is to elucidate on the iatrogenic causes of TCM, allowing for prompt recognition and management by clinicians.
Core Tip: The aim of this review is to elucidate on the iatrogenic causes of Takotsubo cardiomyopathy (TCM). To date, there are individual case reports of iatrogenic TCM but there is not a comprehensive review article. In this review article, we discuss medication and procedure-induced TCM as well as an in-depth review of the current pathophysiology behind TCM.
