LIN28A: A multifunctional versatile molecule with future therapeutic potential

Figure 1 Structure of LIN28 protein. LIN28 paralogs in vertebrates contain relatively conserved cold-shock domains and cysteine cysteine histidine cysteine. LIN28B contains a nuclear localisation signal at the end and is slightly longer than LIN28A. CSD: Cold-shock domains; NLS: Nuclear localisation signal; CCHC: Cysteine cysteine histidine cysteine.

Figure 2 Molecular pathways of LIN28A/let-7 axis. LIN28A binds to pri-let-7 in the nucleus to prevent its processing by Drosha and to pre-let-7 in the cytoplasm to prevent Dicer processing as well as facilitate its degradation.