Copyright ©The Author(s) 2022.
World J Biol Chem. Mar 27, 2022; 13(2): 35-46
Published online Mar 27, 2022. doi: 10.4331/wjbc.v13.i2.35
Figure 1
Figure 1 Structure of LIN28 protein. LIN28 paralogs in vertebrates contain relatively conserved cold-shock domains and cysteine cysteine histidine cysteine. LIN28B contains a nuclear localisation signal at the end and is slightly longer than LIN28A. CSD: Cold-shock domains; NLS: Nuclear localisation signal; CCHC: Cysteine cysteine histidine cysteine.
Figure 2
Figure 2 Molecular pathways of LIN28A/let-7 axis. LIN28A binds to pri-let-7 in the nucleus to prevent its processing by Drosha and to pre-let-7 in the cytoplasm to prevent Dicer processing as well as facilitate its degradation.