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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Mar 27, 2022; 13(2): 35-46
Published online Mar 27, 2022. doi: 10.4331/wjbc.v13.i2.35
Published online Mar 27, 2022. doi: 10.4331/wjbc.v13.i2.35
LIN28A: A multifunctional versatile molecule with future therapeutic potential
Kenneth Wu, Tauseef Ahmad, Rajaraman Eri, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7250, Australia
Author contributions: Wu K wrote the review; all authors have read and approved the final version of the review.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rajaraman Eri, DVM, PhD, Associate Professor, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Health Sciences Building (Newnham-C), 2nd Level, Room M216, Launceston, Tasmania 7250, Australia. rajaraman.eri@utas.edu.au
Received: March 27, 2021
Peer-review started: March 27, 2021
First decision: July 27, 2021
Revised: September 6, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: March 27, 2022
Peer-review started: March 27, 2021
First decision: July 27, 2021
Revised: September 6, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: March 27, 2022
Core Tip
Core Tip: The overexpression of LIN28A has been correlated with a number of tumours and a higher risk of relapse in cancer patients. Therefore, LIN28A could be developed as a prognostic indicator. With an increasing understanding of its roles in the pathological context, LIN28A has also become a promising therapeutic target for cancer treatment and regenerative therapy for neuropathies.