Matsuda T, Muromoto R, Sekine Y, Togi S, Kitai Y, Kon S, Oritani K. Signal transducer and activator of transcription 3 regulation by novel binding partners. World J Biol Chem 2015; 6(4): 324-332 [PMID: 26629315 DOI: 10.4331/wjbc.v6.i4.324]
Corresponding Author of This Article
Tadashi Matsuda, PhD, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan. tmatsuda@pharm.hokudai.ac.jp
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tadashi Matsuda, Ryuta Muromoto, Yuichi Sekine, Sumihito Togi, Yuichi Kitai, Shigeyuki Kon, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
Kenji Oritani, Department of Hematology and Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
Author contributions: All authors contributed to this paper.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tadashi Matsuda, PhD, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan. tmatsuda@pharm.hokudai.ac.jp
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Received: January 20, 2015 Peer-review started: January 20, 2015 First decision: April 10, 2015 Revised: August 24, 2015 Accepted: September 1, 2015 Article in press: September 2, 2015 Published online: November 26, 2015
Core Tip
Core tip: Signal transducer and activator of transcription 3 (STAT3) has been proposed its physiological and pathological significance in malignant and inflammatory diseases; therefore, the targeting of the STAT3 pathways is likely to be suitable for clinical application. In this review, we introduced novel regulatory molecules of STAT3 binding partners, such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2. These proteins positively or negatively regulate critical steps of STAT3-mediated signals via individually unique mechanism. We hope that the information described here will help to develop a new strategy to clinically control the STAT3 activities.
