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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Aug 26, 2014; 5(3): 355-376
Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.355
Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.355
Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants
Sugreev Verma, Kousik Kesh, Nilanjan Ganguly, Sayantan Jana, Snehasikta Swarnakar, Drug Development Diagnostic and Biotechnology Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India
Author contributions: All authors contributed to this paper.
Supported by Council of Scientific and Industrial Research, India; (CSIR)-INDEPTH and HUM projects
Correspondence to: Dr. Snehasikta Swarnakar, Drug Development Diagnostic and Biotechnology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, India. snehasiktas@hotmail.com
Telephone: +91-33-24995824 Fax: +91-33-24735197
Received: April 3, 2014
Revised: May 7, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Revised: May 7, 2014
Accepted: June 10, 2014
Published online: August 26, 2014
Core Tip
Core tip: Matrix metalloproteinases (MMPs), a group of zinc dependent endopeptidases, substantially contribute to extra cellular remodelling, angiogenesis, cellular differentiation, proliferation and apoptosis. MMPs are also important regulators of tumor growth both at the primary site and in distant metastasis; thus the enzymes are considered as important targets for cancer therapy. This review describes the roles and regulation of different MMPs and their subsequent actions over different gastrointestinal cancers both in epigenetic and cellular level. Furthermore, this review summarizes the current state of knowledge of dietary antioxidants in preventing gastrointestinal cancer progression as well as mechanism of action.