Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration

doi:10.4331/wjbc.v16.i2.106850

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 2

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (374)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series.

Item

Count

PDF

HTML

213

Figures (1-2)

Sum=254

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=90

Publishing Process of This Article

Item

Count

Browse

Download

Sum=16

Jun 5, 2025 (publication date) through Jun 5, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Biological Chemistry

ISSN

1949-8454

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Biol Chem. Jun 5, 2025; 16(2): 106850
Published online Jun 5, 2025. doi: 10.4331/wjbc.v16.i2.106850

Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration

Yasmin Garkani Mokhtari, Irene Varnava, Kosmas Kyrgiannis, Vasiliki Ampatsidou, Dimitrios Giakoumettis

Yasmin Garkani Mokhtari, Irene Varnava, Department of Medicine, Basic Biomedical Sciences, Specialization in Stem Cells, Gene-Cell Therapy, Regenerative Medicine, University of Ioannina, Ioannina 45110, Ipeiros, Greece

Kosmas Kyrgiannis, Vasiliki Ampatsidou, Dimitrios Giakoumettis, Department of Neurosurgery, Agios Savvas, General Anticancer Oncological Hospital, Athens 11522, Attikí, Greece

Dimitrios Giakoumettis, Department of Neurosurgery, Democritus University of Thrace, Greece, Alexandroupoli 69100, Anatolikí Makedonía kai Thráki, Greece

Author contributions: Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, and Giakoumettis D contributed to preparing and editing the article; Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, and Giakoumettis D contributed to conceptualizing the article; All authors participated equally in the preparation of the manuscript and read and approved the manuscript.

Conflict-of-interest statement: All authors declare no competing financial interests or personal relationships that could influence the work presented in this manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Dimitrios Giakoumettis, Consultant, MD, PhD, Post Doctoral Researcher, Department of Neurosurgery, Agios Savvas, General Anticancer Oncological Hospital, 171 Alexandras Avenue, Athens 11522, Attikí, Greece. dgiakoumettis@gmail.com

Received: March 9, 2025
Revised: March 31, 2025
Accepted: April 9, 2025
Published online: June 5, 2025
Processing time: 82 Days and 9.8 Hours

Core Tip

Core Tip: Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopamine neurons in the substantia nigra. Currently, there is no treatment for PD, while stem cell therapy represents a new therapeutic approach to restore lost neural function. This manuscript focused on the potential of stem cell therapy, particularly induced pluripotent stem cells and human pluripotent stem cells, in treating PD, offering potential for neuronal replacement and restoration of brain function. Induced pluripotent stem cells are derived from reprogramming adult cells, which are genetically compatible and cause reduced immune rejection, overcoming ethical concerns associated with embryonic stem cells.