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World J Biol Chem. Jun 5, 2025; 16(2): 106850
Published online Jun 5, 2025. doi: 10.4331/wjbc.v16.i2.106850
Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration
Yasmin Garkani Mokhtari, Irene Varnava, Kosmas Kyrgiannis, Vasiliki Ampatsidou, Dimitrios Giakoumettis
Yasmin Garkani Mokhtari, Irene Varnava, Department of Medicine, Basic Biomedical Sciences, Specialization in Stem Cells, Gene-Cell Therapy, Regenerative Medicine, University of Ioannina, Ioannina 45110, Ipeiros, Greece
Kosmas Kyrgiannis, Vasiliki Ampatsidou, Dimitrios Giakoumettis, Department of Neurosurgery, Agios Savvas, General Anticancer Oncological Hospital, Athens 11522, Attikí, Greece
Dimitrios Giakoumettis, Department of Neurosurgery, Democritus University of Thrace, Greece, Alexandroupoli 69100, Anatolikí Makedonía kai Thráki, Greece
Author contributions: Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, and Giakoumettis D contributed to preparing and editing the article; Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, and Giakoumettis D contributed to conceptualizing the article; All authors participated equally in the preparation of the manuscript and read and approved the manuscript.
Conflict-of-interest statement: All authors declare no competing financial interests or personal relationships that could influence the work presented in this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dimitrios Giakoumettis, Consultant, MD, PhD, Post Doctoral Researcher, Department of Neurosurgery, Agios Savvas, General Anticancer Oncological Hospital, 171 Alexandras Avenue, Athens 11522, Attikí, Greece. dgiakoumettis@gmail.com
Received: March 9, 2025
Revised: March 31, 2025
Accepted: April 9, 2025
Published online: June 5, 2025
Processing time: 82 Days and 9.8 Hours
Core Tip

Core Tip: Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopamine neurons in the substantia nigra. Currently, there is no treatment for PD, while stem cell therapy represents a new therapeutic approach to restore lost neural function. This manuscript focused on the potential of stem cell therapy, particularly induced pluripotent stem cells and human pluripotent stem cells, in treating PD, offering potential for neuronal replacement and restoration of brain function. Induced pluripotent stem cells are derived from reprogramming adult cells, which are genetically compatible and cause reduced immune rejection, overcoming ethical concerns associated with embryonic stem cells.